Bullets don't show in Outlook 2010 and "back to top" doesn't work :-(

Hi All
Close to final mail out and now I've discovered that my bullets in my <ul> don't show in Outlook 2010 they do in Outlook 2007 and Entourage.

I also have "back to top" links which while they work in the browser version and Entourage, don't work in Outlook 2010 or 2007. Ideally I'd like these to link to just under the welcome letter which is below my banner, where the contents list is.

Does anyone have any ideas please?

Here's my code:

<html lang="en">
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    <title>SPHERE_0711</title>
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    a:hover { text-decoration: none !important; }
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    .content h2 {color:#0063be !important; font-weight: bold; margin: 0; padding: 0; line-height: 30px; font-size: 17px; font-family: Verdana, Arial, sans-serif;}
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    .content a {color:#fa943e; text-decoration: none;}
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    .footer a {color: #efe08e; text-decoration: none; border-bottom: 1px dotted #efe08e}
    .notice p {margin: 0; padding: 0; text-align: center;color:#fa943e; font-family: Georgia, serif;}
    .notice a {color: #efe08e; text-decoration: none; border-bottom: 1px dotted #efe08e}
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                <p style="margin: 0; padding: 0; text-align: center;color:#fa943e; font-family: Georgia, serif;">Can't see this email? <webversion style="color:white; text-decoration: none; border-bottom: 1px dotted #fa943e">Click here</webversion> to view it in your browser.</p>
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                      <h1 style="color: white; font: bold 22px Verdana, Arial, sans-serif; margin: 0; padding: 0; line-height: 30px;">Welcome</h1>
                        <p style="color: white; font: normal 12px Verdana, Arial, sans-serif; margin: 0; padding-right: 20px; line-height: 22px; ">Dear SPHERE colleagues,<br>
Welcome to the first issue of <em>SPHERE Connect</em>, the official SPHERE newsletter that will inform you of developments in HER2 testing, update you on the SPHERE programme’s progress and keep you in contact with your colleagues throughout the SPHERE region.<br>
It has been several months since we first met under the SPHERE banner, and I am happy to report that the SPHERE roll-out meetings are going from strength to strength. The national phases of the training programme have been launched and have reached our colleagues across the Asia Pacific region in China, South Korea, Thailand, Malaysia, Indonesia, Vietnam, the Philippines, Hong Kong and Taiwan.<br>
The programme itself continues to evolve. Within this first edition of <em>SPHERE Connect</em>, we introduce the SPHERE Clinical Audit. This will produce the region’s first HER2 testing database in breast and gastric cancer which will be of great assistance in achieving best practice in HER2 testing. Needless to say, SPHERE participants will figure prominently in this project.<br> 
<img src="Images/M_Bilous.jpg" alt="Michael" width="174" height="202" align="right">
This newsletter also features updates from the recent American Society of Clinical Oncology (ASCO<sup>&reg;</sup>) meeting in Chicago, alongside developments across the region.<br>
<em>SPHERE Connect</em> is very much your platform to connect, share and debate with colleagues. We welcome your contributions; your experiences, cases and especially your feedback. For more details on how to submit your ideas, see the section “<em>SPHERE Connect is your voice!</em>� . We look forward to hearing from you and hope that <em>SPHERE Connect</em> will prove to be a valuable resource.<br>
Michael Bilous                        
                    <p style="color: white; font: normal 12px Verdana, Arial, sans-serif; margin: 0; padding-right: 20px; line-height: 22px; "><img src="Images/MichaelBilousSignature.png" width="206" height="51" alt="Signature"></td>
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                                <h3 style="color:#fa943e; font-weight: bold; margin: 0; padding: 0; line-height: 18px; font-size: 20px;font-family: Verdana, Arial, sans-serif;">Don't miss...</h3>
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                            <td width="11" style="font-size: 1px; line-height: 1px;">&nbsp;</td>
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                              <h3 style="color:#0063be; font-weight: bold; margin: 0; padding: 0; line-height: 13px; font-size: 15px;font-family: Verdana, Arial, sans-serif;">SPHERE Newswire</h3>
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                                <h4 style="color:#fa943e; font-size: 11px;line-height: 16px; margin: 0; padding: 0;"><a href="#controversies" style="color: #fa943e; text-decoration: none; border-bottom: 1px dotted #fa943e">Controversies in HER2 testing</a></h4>
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                            <td width="7" style="font-size: 1px; line-height: 1px;">&nbsp;</td>
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                                <h4 style="color:#fa943e; font-size: 11px;line-height: 16px; margin: 0; padding: 0;"><a href="#breast" style="color: #fa943e; text-decoration: none; border-bottom: 1px dotted #fa943e">Breast cancer prevention and treatment</a></h4>
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                              <h3 style="color:#0063be; font-weight: bold; margin: 0; padding: 0; line-height: 13px; font-size: 15px;font-family: Verdana, Arial, sans-serif;">SPHERE Updates</h3>
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                              <h4 style="color:#fa943e; font-size: 11px;line-height: 16px; margin: 0; padding: 0;"><a href="#regionalaudit" style="color: #fa943e; text-decoration: none; border-bottom: 1px dotted #fa943e">The Regional Clinical Audit</a></h4>
                            
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                              <h4 style="color:#fa943e; font-size: 11px;line-height: 16px; margin: 0; padding: 0;"><a href="#Developments" style="color: #fa943e; text-decoration: none; border-bottom: 1px dotted #fa943e">Developments across the region</a></h4>
                            
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                                <h3 style="color:#0063be; font-weight: bold; margin: 0; padding: 0; line-height: 17px; font-size: 15px;font-family: Verdana, Arial, sans-serif;"><i>SPHERE Connect</i> quiz</h3>
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                                <h4 style="color:#fa943e; font-size: 11px;line-height: 16px; margin: 0; padding: 0;"><a href="#Quiz" style="color: #fa943e; text-decoration: none; border-bottom: 1px dotted #fa943e">HER2 Cases with Michael Bilous</a></h4>                
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                                <h3 style="color:#0063be; font-weight: bold; margin: 0; padding: 0; line-height: 13px; font-size: 15px;font-family: Verdana, Arial, sans-serif;">SPHERE Tips</h3>
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                                <h4 style="color:#fa943e; font-size: 11px;line-height: 16px; margin: 0; padding: 0;"><a href="#tips" style="color: #fa943e; text-decoration: none; border-bottom: 1px dotted #fa943e">From the laboratory...</a></h4>                
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                            <td style="padding: 15px 0 5px; font-family: Georgia, serif;"  valign="top" align="left">
                              <h3 style="color:#0063be; font-weight: bold; margin: 0; padding: 0; line-height: 17px; font-size: 15px;font-family: Verdana, Arial, sans-serif;"><i>SPHERE Connect</i> is your voice!</h3>
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                            <td width="7" style="font-size: 1px; line-height: 1px;">&nbsp;</td>
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                                <h4 style="color:#fa943e; font-size: 11px;line-height: 16px; margin: 0; padding: 0;"><a href="#voice" style="color: #fa943e; text-decoration: none; border-bottom: 1px dotted #fa943e">Have your say...</a></h4>                        
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                                <h3 style="color:#0063be; font-weight: bold; margin: 0; padding: 0; line-height: 13px; font-size: 15px;font-family: Verdana, Arial, sans-serif;">Forward to a friend</h3>
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                                <p style="line-height: 16px; font-family: Verdana, Arial, sans-serif; color:#fa943e;padding: 0; margin: 0;">Know someone who might be interested in <i>SPHERE Connect</i>? Why not 
                                  <forwardtoafriend style="color: #0063be; text-decoration: none; border-bottom: 1px dotted #0063be">forward this email</forwardtoafriend> to them.</p>                    </td>
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                                <h2 style="color:#0063be; font-weight: bold; margin: 0; padding: 0; line-height: 28px; font-size: 17px; font-family: Verdana, Arial, sans-serif;">SPHERE Newswire: Updates from ASCO<sup>&reg;</sup> Annual Meeting, 4–8 June 2011, Chicago, US</h2><br>
                                <img src="Images/Chicago_PDsmall.png" width="370" height="246" alt="Chicago scene"><br>
                              <h2 style="color:#0063be; font-weight: normal; margin: 0; padding: 0; line-height: 24px; font-size: 17px; font-family: Verdana, Arial, sans-serif;">&nbsp;</h2>
                              <h2 style="color:#0063be; font-weight: normal; margin: 0; padding: 0; line-height: 24px; font-size: 17px; font-family: Verdana, Arial, sans-serif;"><a name="controversies">Controversies in HER2 testing</a></h2>
                                <p style="color:#0063be; font-weight: normal; margin: 0; padding: 0; line-height: 20px; font-size: 12px;">
                                    Variations in HER2 test results not only reflect technical problems, but also the imperfect assumptions that currently guide testing guidelines and scoring criteria, as highlighted Professor Giuseppe Viale of the European Institute of Oncology, University of Milan.<br>
Professor Viale emphasised the necessity for greater collaboration between oncologists and pathologists to address problematic cases that affect prescriptions of HER2-targeted treatments. His review of the scoring process raised several uncertainties related to diagnostic thresholds for determining HER2 positivity, reclassification of HER2 positivity status in metastatic tumours, identification of genuine polysomy cases, suitability of HER2/CEP17 as a scoring parameter and HER2 classification in intratumoural heterogeneity.<br>
He provided several suggestions to address these uncertainties.
                                <ul style="color: #0063be; margin: 0 0 0 10px; padding: 0 0 0 5px; line-height: 20px; font-size: 12px;font-family: Georgia, serif;">
                    <li>When HER2 status changes, retest the primary tumour and metastases simultaneously to rule out technical variations, preferably with alternative assays.</li> 
                    <li>If overexpression is present in less than 10% of cells, assess HER2 status in all blocks of the primary tumour and report actual percentages as the patient may benefit from re-biopsy.</li>
                    <li>The HER2 gene count number is more appropriate than the HER2/CEP17 ratio for establishing amplification in polysomic cases.</li> 
                    <img src="Images/SphereFACTOID.png" alt="Factoid" width="198" height="210" align="right">
                    <li>For intratumoural heterogeneity, double staining of the same specimen allows identification of individual tumour cells with HER2 gene amplification and overexpression.</li></p>
                    </ul>

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                                <h2 style="color:#51652a; font-weight: normal; margin: 0; padding: 0; line-height: 24px; font-size: 17px;"><a name="breast">Breast cancer prevention and treatment</a></h2>
            
                                <p style="color:#0063be; font-weight: normal; margin: 0; padding: 0; line-height: 20px; font-size: 12px;">The 2011 ASCO<sup>&reg;</sup> Annual Meeting provided significant insights into the prevention and treatment of breast cancer, summarised Dr Stephen R. D. Johnston of the Royal Marsden Hospital, London.<br>
                                  The MAP 3 trial results were among the more significant developments in breast cancer prevention among high-risk patients. These results demonstrated a reduction in annual cancer incidence from 0.55% with placebo to 0.19% with exemestane, an aromatase inhibitor. This translates into a 65% risk reduction. Furthermore, treatment with exemestane was well-tolerated, which may significantly benefit patients who face rare but serious side effects with the current gold standard, tamoxifen.<sup>1</sup> <br>
                                  Dual targeting of HER2 positive breast cancers in the neoadjuvant setting also emerged as a promising treatment strategy. The combination of lapatinib and trastuzumab with antracycline- or taxane-based chemotherapy produced higher pathological complete remission rates compared with single agent combinations with chemotherapy.<sup>2,3</sup> The TBCRC 006 trial demonstrated the efficacy of dual targeting in the absence of chemotherapy, with the addition of endocrine therapy in hormone-positive patients. However, treatment duration must be extended due to the slow development of hormone-positive tumours.<sup>4</sup><br>
                                Dr Johnston concluded that emerging evidence suggested that cell proliferation rates may be able to predict prognosis and determine responsiveness to treatment, particularly in hormone-positive breast cancer.</p>
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                                <h2 style="color:#0063be; font-weight: bold; margin: 0; padding: 0; line-height: 24px; font-size: 17px; font-family: Verdana, Arial, sans-serif;">SPHERE Updates</h2>
                                <h2 style="color:#0063be; font-weight: normal; margin: 0; padding: 0; line-height: 24px; font-size: 17px; font-family: Verdana, Arial, sans-serif;"><a name="regionalaudit">The Regional Clinical Audit</a></h2>
                            <p style="color:#0063be; font-weight: normal; margin: 0; padding: 0; line-height: 20px; font-size: 12px;">
                                    It is finally here; enrolment for the SPHERE Clinical Audit that will build the first regional HER2 testing database for breast and gastric cancer begins this month. Data compiled will provide insights into centre-, country- and region-specific positivity rates; detect trends in the number of HER2 tests performed and establish the epidemiology of HER2 positive cancers.<br>
The audit encourages best practice and will give you the opportunity to measure your laboratory’s HER2 testing performance, gain expert advice to troubleshoot testing variations, participate in publication opportunities and establish networks with peers and key opinion leaders.<br>
The pilot phase of the audit will run from August 2011 to February 2012; all SPHERE-trained centres across the Asia Pacific region are invited to participate. Before enrolling in the audit, do take the time to understand the protocol thoroughly and clarify:
                            <ul style="color: #0063be; margin: 0 0 0 10px; padding: 0 0 0 5px; line-height: 20px; font-size: 12px;font-family: Georgia, serif;">
                            <li>data release or patient confidentiality requirements in your institution or country</li>
                            <li>laboratory readiness to undertake data collection.</li>
                            </ul>
                        <p style="color:#0063be; font-weight: normal; margin: 0; padding: 0; line-height: 20px; font-size: 12px;">Your local Roche representative will contact you shortly with further details and the following supporting materials:</p>
                        <ul style="color: #0063be; margin: 0 0 0 10px; padding: 0 0 0 5px; line-height: 20px; font-size: 12px;font-family: Georgia, serif;">
                            <li>the clinical audit protocol</li>
                            <li>data collection spreadsheet</li>
                            <li>guidance documentation on data collection</li>
                            <li>frequently asked questions.</li>
</ul>
                            <p style="color:#0063be; font-weight: normal; margin: 0; padding: 0; line-height: 20px; font-size: 12px;">If you require further information about the audit, do drop us a line at <a href="mailto:sphere.audit@healthinteractions.com">sphere.audit@healthinteractions.com</a>. We look forward to your participation in this landmark audit.</p>
    <p style="font-size: 10px; font-family: Verdana, Geneva, sans-serif; line-height: 12px; text-align: right; color: #fa943e"><a href="#top">back to top</a>
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                                <h2 style="color:#0063be; font-weight: normal; margin: 0; padding: 0; line-height: 24px; font-size: 17px; font-family: Verdana, Arial, sans-serif;"><a name="Developments">Developments across the region</a></h2>
                                <h2 style="color:#0063be; font-weight: normal; margin: 0; padding: 0; line-height: 24px; font-size: 17px; font-family: Verdana, Arial, sans-serif;">&nbsp;</h2>
                    <div>
                      <div style="background: #bae2f8; padding-left: 5px; padding-right: 5px; padding-top: 10px; padding-bottom: 5px; color: #FFF">
                            <img src="Images/kr.png" width="80" height="80" alt="Korea" align=right>
                            <h1 style="color:#0063be; font: bold 16px Verdana, Arial, sans-serif; margin: 0; padding: 0; line-height: 20px;">SPHERE – South Korea</h1>
                    <ul p style="font-size: 12px; margin: 5 5 0 15px; font-family: Verdana, Geneva, sans-serif; line-height: 20px; color:#0063be;">
                    <li>Aims to train 82 centres by year end</li>
                            <li>Greater focus on gastric cancer testing and the importance of automation</li>
                            <li>Endorsed by Korean Society of Pathologists</li>
                            <li>Initiatives include securing reimbursement for HER2 testing of early breast cancer patients and encouraging multidisciplinary communication in HER2 testing</li>
                        </ul>
                    </div>
                 <p style="color:#0063be; font-weight: normal; margin: 0; padding: 0; line-height: 20px; font-size: 12px;">&nbsp;</p>
                     <div>
                          <div style="background: #bae2f8; padding-left: 5px; padding-right: 5px; padding-top: 10px; padding-bottom: 5px; color: #FFF">
                        <img src="Images/cn.png" width="80" height="80" alt="China" align=right>
                        <h1 style="color:#0063be; font: bold 16px Verdana, Arial, sans-serif; margin: 0; padding: 0; line-height: 20px;">SPHERE – China</h1>
                        <ul p style="font-size: 12px; margin: 5 5 0 15px; font-family: Verdana, Geneva, sans-serif; line-height: 20px; color:#0063be;">
                            <li>Aims to train 280 centres by year end</li>
                            <li>Program adapted to address specific barriers with HER2 testing through collaborations  with the Pathology Quality Control Centre (PQCC) and the Chinese Anti-Cancer Association (CACA)</li>
                            <li>Initiatives include pushing towards automation and launch of clinical audit</li>
                        </ul>
                    </div>
                 <p style="color:#0063be; font-weight: normal; margin: 0; padding: 0; line-height: 20px; font-size: 12px;">&nbsp;</p>
                    <div>
                          <div style="background: #bae2f8; padding-left: 5px; padding-right: 5px; padding-top: 10px; padding-bottom: 5px; color: #FFF">
                        <img src="Images/vn.png" width="80" height="80" alt="Vietnam" align=right>
                        <h1 style="color:#0063be; font: bold 16px Verdana, Arial, sans-serif; margin: 0; padding: 0; line-height: 20px;">SPHERE – Vietnam</h1>
                        <ul p style="font-size: 12px; margin: 5 5 0 15px; font-family: Verdana, Geneva, sans-serif; line-height: 20px; color:#0063be;">
                            <li>Aims to train 11 centres in the SPHERE program by year end</li>
                            <li>Initiatives include supporting establishment of reference laboratories and encouraging external quality assurance (QA) programme enrolment</li>
                        </ul>
                    </div>
                 <p style="color:#0063be; font-weight: normal; margin: 0; padding: 0; line-height: 20px; font-size: 12px;">&nbsp;</p>
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                          <div style="background: #bae2f8; padding-left: 5px; padding-right: 5px; padding-top: 10px; padding-bottom: 5px; color: #FFF">
                        <img src="Images/th.png" width="80" height="80" alt="Thailand" align=right>
                        <h1 style="color:#0063be; font: bold 16px Verdana, Arial, sans-serif; margin: 0; padding: 0; line-height: 20px;">SPHERE – Thailand</h1>
                        <ul p style="font-size: 12px; margin: 5 5 0 15px; font-family: Verdana, Geneva, sans-serif; line-height: 20px; color:#0063be;">
                            <li>Aims to train 11 centres by year end</li>
                            <li>Highlights clinical audit participation, multidisciplinary communication and automation in HER2 testing</li>
                            <li>Initiatives include supporting establishment of reference laboratories and development of national guidelines for HER2 testing</li>
                        </ul>
                    </div>
                 <p style="color:#0063be; font-weight: normal; margin: 0; padding: 0; line-height: 20px; font-size: 12px;">&nbsp;</p>
                    <div>
                          <div style="background: #bae2f8; padding-left: 5px; padding-right: 5px; padding-top: 10px; padding-bottom: 5px; color: #FFF">
                        <img src="Images/id.png" width="80" height="80" alt="Indonesia" align=right>
                        <h1 style="color:#0063be; font: bold 16px Verdana, Arial, sans-serif; margin: 0; padding: 0; line-height: 20px;">SPHERE – Indonesia</h1>
                        <ul p style="font-size: 12px; margin: 5 5 0 15px; font-family: Verdana, Geneva, sans-serif; line-height: 20px; color:#0063be;">
                            <li>Seventeen centres enrolled in SPHERE to-date</li>
                            <li>Endorsed by the Indonesian Association of Pathologists (IAPI)</li>
                            <li>Initiatives include supporting an on-going HEROES study that assesses HER2 overexpression in breast cancer in Indonesia and to drive the development of IAPI QC and QA national guidelines</li>
                        </ul>
                    </div>
                 <p style="color:#0063be; font-weight: normal; margin: 0; padding: 0; line-height: 20px; font-size: 12px;">&nbsp;</p>
                     <div>
                          <div style="background: #bae2f8; padding-left: 5px; padding-right: 5px; padding-top: 10px; padding-bottom: 5px; color: #FFF">
                        <img src="Images/ph.png" width="80" height="80" alt="Philippines" align=right>
                        <h1 style="color:#0063be; font: bold 16px Verdana, Arial, sans-serif; margin: 0; padding: 0; line-height: 20px;">SPHERE – Philippines</h1>
                        <ul p style="font-size: 12px; margin: 5 5 0 15px; font-family: Verdana, Geneva, sans-serif; line-height: 20px; color:#0063be;">
                            <li>Expanded training schedule to encompass 18 testing centres nationwide</li> 
                            <li>Ten centres are enrolled with the UK-NEQAS QA programme</li>
                            <li>Initiatives include gaining commitment  from top-tier pathologists and technicians and improving multidisciplinary communications</li>
                        </ul>
                    </div>
                 <p style="color:#0063be; font-weight: normal; margin: 0; padding: 0; line-height: 20px; font-size: 12px;">&nbsp;</p>
                    <div>
                          <div style="background: #bae2f8; padding-left: 5px; padding-right: 5px; padding-top: 10px; padding-bottom: 5px; color: #FFF">
                        <img src="Images/hk.png" width="80" height="80" alt="Hong Kong" align=right>
                        <h1 style="color:#0063be; font: bold 16px Verdana, Arial, sans-serif; margin: 0; padding: 0; line-height: 20px;">SPHERE – Hong Kong</h1>
                        <ul p style="font-size: 12px; margin: 5 5 0 15px; font-family: Verdana, Geneva, sans-serif; line-height: 20px; color:#0063be;">
                            <li>Aims to train 10 centres by year end</li>
                            <li>Encourages routine HER2 testing in gastric cancer</li>
                            <li>Initiatives include gaining commitment from top-tier pathologists and technicians and improving multidisciplinary communications</li>
                        </ul>
                    </div>
                 <p style="color:#0063be; font-weight: normal; margin: 0; padding: 0; line-height: 20px; font-size: 12px;">&nbsp;</p>
                    <div>
                          <div style="background: #bae2f8; padding-left: 5px; padding-right: 5px; padding-top: 10px; padding-bottom: 5px; color: #FFF">
                        <img src="Images/tw.png" width="80" height="80" alt="Taiwan" align=right>
                        <h1 style="color:#0063be; font: bold 16px Verdana, Arial, sans-serif; margin: 0; padding: 0; line-height: 20px;">SPHERE – Taiwan</h1>
                        <ul p style="font-size: 12px; margin: 5 5 0 15px; font-family: Verdana, Geneva, sans-serif; line-height: 20px; color:#0063be;">
                            <li>Will train 21 centres by year end</li> 
                            <li>Includes focus on gastric cancer sample handling in laboratories</li>
                            <li>Initiatives include engaging with surgeons and oncologists and clinical audit participation</li>
                        </ul>
                    </div>
                 <p style="color:#0063be; font-weight: normal; margin: 0; padding: 0; line-height: 20px; font-size: 12px;">&nbsp;</p>
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                          <div style="background: #bae2f8; padding-left: 5px; padding-right: 5px; padding-top: 10px; padding-bottom: 5px; color: #FFF">
                        <img src="Images/my.png" width="80" height="80" alt="Malaysia" align=right>
                        <h1 style="color:#0063be; font: bold 16px Verdana, Arial, sans-serif; margin: 0; padding: 0; line-height: 20px;">SPHERE – Malaysia</h1>
                        <ul p style="font-size: 12px; margin: 5 5 0 15px; font-family: Verdana, Geneva, sans-serif; line-height: 20px; color:#0063be;">
                            <li>Expanded to train 26 centres</li>
                            <li>Initiatives include multidisciplinary engagement, epidemiology study and clinical audit participation</li>
                        </ul>
                    </div>
                 <p style="color:#0063be; font-weight: normal; margin: 0; padding: 0; line-height: 20px; font-size: 12px;">&nbsp;</p>                                                   
                        <p style="font-size: 10px; font-family: Verdana, Geneva, sans-serif; line-height: 30px; text-align: right; color: #fa943e"><a href="#top">back to top</a>
    <br></p>

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                          <h2 style="color:#0063be; font-weight: bold; margin: 0; padding: 0; line-height: 24px; font-size: 17px; font-family: Verdana, Arial, sans-serif;"><i>SPHERE Connect</i> quiz</h2>
                                <h2 style="color:#0063be; font-weight: normal; margin: 0; padding: 0; line-height: 24px; font-size: 17px; font-family: Verdana, Arial, sans-serif;"><a name="Quiz">HER2 Cases with Michael Bilous</a></h2>
                            <p style="color:#0063be; font-weight: normal; margin: 0; padding: 0; line-height: 20px; font-size: 12px;">The cases below show the staining results of a range of breast and gastric cancer specimens. Test your HER2 scoring skills by  
                            <a href=http://www.surveymonkey.com/s/TJKGSV3> clicking here</a> and completing our quick quiz. Once you have entered your response, the corresponding score, as recommended by Michael Bilous will instantly be revealed to you. Good luck!<br></p>
                            <p style="color:#0063be; font-weight: normal; margin: 0; padding: 0; line-height: 20px; font-size: 12px;">&nbsp;</p>                            
                            <h1 style="color:#0063be; font: bold 14px Verdana, Arial, sans-serif; margin: 0; padding: 0; line-height: 20px;">Case 1</h1><br>
                            <p style="color:#0063be; font-weight: normal; margin: 0; padding: 0; line-height: 20px; font-size: 12px;">How would you score the HER2 IHC stain of this breast cancer? The antibody used is 4B5 on a Ventana Benchmark instrument.<br>
                            &nbsp;
                           </p>
                            <img src="Images/case_1_1.png" width="370" height="278" alt="Case1_1">
                            <p style="color:#0063be; font:Verdana, Arial, sans-serif; normal; margin: 0; padding: 0; line-height: 20px; font-size: 12px;">IHC stain</p>
                            <img src="Images/case_1_2.png" width="370" height="278" alt="Case1_2">
                            <p style="color:#0063be; font:Verdana, Arial, sans-serif; normal; margin: 0; padding: 0; line-height: 20px; font-size: 12px;">HE stain</p>
                            <p style="color:#0063be; font-weight: normal; margin: 0; padding: 0; line-height: 20px; font-size: 12px;">&nbsp;</p>                            
                            <h1 style="color:#0063be; font: bold 14px Verdana, Arial, sans-serif; margin: 0; padding: 0; line-height: 20px;">Case 2</h1><br>
                            <p style="color:#0063be; font-weight: normal; margin: 0; padding: 0; line-height: 20px; font-size: 12px;">This is a well differentiated invasive gastric adenocarcinoma of intestinal type, excision specimen. How would you score this HER2 slide stained by antibody 4B5?<br>
                            &nbsp;
                           </p>                            
                            <img src="Images/Case_2.png" width="370" height="278" alt="Case2_1"> 
                            &nbsp;
                           </p>
                            <p style="color:#0063be; font-weight: normal; margin: 0; padding: 0; line-height: 20px; font-size: 12px;">&nbsp;</p>
                           <h1 style="color:#0063be; font: bold 14px Verdana, Arial, sans-serif; margin: 0; padding: 0; line-height: 20px;">Case 3</h1><br> 
                           <p style="color:#0063be; font-weight: normal; margin: 0; padding: 0; line-height: 20px; font-size: 12px;">Below is an invasive breast carcinoma, No Special Type grade 3. The carcinoma cells showed marked cytological atypia and a high mitotic rate. How would you score the HER2 IHC stain shown? The antibody used is 4B5.<br>
                            &nbsp;
                           </p>
                           <img src="Images/Case_3_1.png" width="370" height="278" alt="Case3_1">
                           <p style="color:#0063be; font-weight: normal; margin: 0; padding: 0; line-height: 20px; font-size: 12px;">&nbsp;</p>                            
                           <img src="Images/Case_3_2.png" width="370" height="278" alt="Case3_2">
                           <p style="color:#0063be; font-weight: normal; margin: 0; padding: 0; line-height: 20px; font-size: 12px;">&nbsp;</p>                            

                           <p style="font-size: 10px; font-family: Verdana, Geneva, sans-serif; line-height: 12px; text-align: right; color: #fa943e"><a href="#top">back to top</a>
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                            <h2 style="color:#0063be; font-weight: bold; margin: 0; padding: 0; line-height: 24px; font-size: 17px; font-family: Verdana, Arial, sans-serif;">SPHERE Tips</h2>
                            <h2 style="color:#0063be; font-weight: normal; margin: 0; padding: 0; line-height: 24px; font-size: 17px; font-family: Verdana, Arial, sans-serif;"><a name="tips">From the laboratory...</a></h2>
                                <h2 style="color:#0063be; font-weight: normal; margin: 0; padding: 0; line-height: 24px; font-size: 17px; font-family: Verdana, Arial, sans-serif;">&nbsp;</h2>                   
                                
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                          <div style="background: #fa943e; padding-left: 5px; padding-right: 5px; padding-top: 10px; padding-bottom: 5px; color: #FFF">
                        <ul p style="font-size: 12px; margin: 0 5 10 15px; font-family: Verdana, Geneva, sans-serif; line-height: 20px; color: white;">
                        <li><b>Validate</b> – Validation of materials and methods builds reliability and reproducibility into testing procedures. Ensure that every phase of the HER2 testing protocol for both breast and gastric cancer specimens are validated, documented and adhered to in the final protocols. Changes to the testing method or reagents, however minor, can introduce variations and must be revalidated.</li>
                        <li><b>Standardise documentation</b> – Document each testing phase, along with the final results of each test performed, in standardised log books and forms. This improves traceability and the detection of sources of variation.</li>
                        <li><b>Mount scoring criteria next to microscopes</b> – Maintain clear visual examples of the validated scoring criteria next to each microscope in your laboratory. The visual guide provides perspective for each case (especially when there are multiple cases to be scored) and improves detection of staining problems.</li>
                    </ul>
                        <img src="Images/Microscopes.png" width="370" height="246" alt="Microscopes"></div>
                        <p style="font-size: 10px; font-family: Verdana, Geneva, sans-serif; line-height: 30px; text-align: right; color: #fa943e"><a href="#top">back to top</a>
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                            <h2 style="color:#0063be; font-weight: bold; margin: 0; padding: 0; line-height: 24px; font-size: 17px; font-family: Verdana, Arial, sans-serif;"><i>SPHERE Connect</i> is your voice!</h2>
                            <img src="Images/megaphone.png" width="150" height="132" alt="megaphone" align=right>
                            <h2 style="color:#0063be; font-weight: normal; margin: 0; padding: 0; line-height: 24px; font-size: 17px; font-family: Verdana, Arial, sans-serif;"><a name="voice">Have your say...</a></h2>
                            <p style="color:#0063be; font-weight: normal; margin: 0; padding: 0; line-height: 20px; font-size: 12px;"><i>SPHERE Connect</i> is the first step in building the HER2 testing network. You are an important part of this network. We are now gathering ideas for our December issue and would love to hear from you. Take this opportunity to:</p>
                            <ul style="color: #0063be; margin: 0 0 0 10px; padding: 0 0 0 5px; line-height: 20px; font-size: 12px;font-family: Georgia, serif;">
                            <li>tell your peers about your initiatives to improve HER2 testing in your laboratory and the challenges that had to be overcome along the way</li>
                            <li>share case studies that challenged your team</li>
                            <li>inspire your peers with your efforts to build better cooperation within the multidisciplinary HER2 testing team to improve patient care</li>
                            <li>tell us how you would like to see <i>SPHERE Connect</i> evolve to better fulfil your requirements.</li>
                        </ul>
                        <p style="color:#0063be; font-weight: normal; margin: 0; padding: 0; line-height: 20px; font-size: 12px;">Please submit your articles (approximately 250 words in length) in English, as a Word document (“.doc�  or “.docx�  attachment), to <a href="mailto:sphere.connect@healthinteractions.com">sphere.connect@healthinteractions.com</a> by 1 November 2011. <i>SPHERE Connect</i> reserves the right to edit all articles for brevity, language, style and grammatical correctness. The edited article is sent back to the writer for verification and consent/approval.</p>
                        <p style="font-size: 10px; font-family: Verdana, Geneva, sans-serif; line-height: 30px; text-align: right; color: #fa943e"><a href="#top">back to top</a>
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                            <h2 style="color:#0063be; font-weight: normal; margin: 0; padding: 0; line-height: 18px; font-size: 14px; font-family: Verdana, Arial, sans-serif;"><a name="tips">References</a></h2>
                               <ol p style="font-size: 10px; margin: 0 0 0 10px; padding: 0 0 0 10px; font-family: Verdana, Geneva, sans-serif; line-height: 14px; color: #0063be;">
                            <li>Goss PE, <i>et al</i>. <i>N Engl J Med</i> 2011;364:2381-2391.</li>
                            <li>Guarneri V, <i>et al</i>. Presented at <i>ASCO</i>. Chicago, US, 4–8 June 2011; Abstract 507.</li> 
                            <li>Holmes FA, <i>et a</i>l. Presented at <i>ASCO</i>. Chicago, US,  4–8 June 2011; Abstract 508.</li>
                            <li>Chang J, <i>et al</i>. Presented at <i>ASCO</i>. Chicago, US,  4–8 June 2011. Abstract 505.</li>
                        </ol>
                             <p style="font-size: 10px; margin: 0 0 0 10px; padding: 0 0 0 10px; font-family: Verdana, Geneva, sans-serif; line-height: 14px; color: #0063be;">Flags courtesy of <a href=http://www.nordicfactory.com>www.nordicfactory.com</a></p>
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Thanks very much again!

roshodgekiss roshodgekiss, 5 years ago

Hi AliGee, good to see you again. With bullet links, try using:

.sidebar ul { margin-left: 1.5em; }

Bulleted lists tend to get truncated in Outlook and just need to have margin-left defined.

Secondly, anchor links can be quite problematic in email. You'll see in that linked post that "linked element(s) display ~ 100px below the top of the preview pane", which is something we can't get around on our end, I'm sorry to say.

Let us know if you have any other questions - good luck with your campaign!


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AliGee AliGee, 5 years ago

Aww thanks roshodgekiss. Will check this out on Monday.

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